Lung Cancer Promotion by Air Pollutants talk - Dr William Hill

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Hear from Dr William Hill from the Francis Crick Institute who will provide an interesting and insightful talk about Lung Cancer on Tuesday 22nd November 2023 at 5 pm. This talk will be held on Microsoft Teams and tickets are FREE!

 

The talk is titled Lung Cancer Promotion by Air Pollutants.

 

Abstract:

A complete understanding of how environmental exposures promote cancer formation is lacking. Over 70 years ago, tumour formation was proposed to occur in a two-step process: an initiating step which induces mutations in normal cells, followed by a promoter step which triggers cancer development. We hypothesised that environmental particulate matter measuring <2.5μm (PM2.5), known to be associated with lung cancer risk, promotes EGFR mutant lung cancer by acting on cells harbouring pre-existing oncogenic mutations in normal lung tissue. We combine epidemiological evidence, functional pre-clinical mouse models and ultra-deep sequencing of normal tissue from clinical cohorts to decipher potential mechanisms of air pollutant-induced tumour promotion. We propose that PM2.5 can trigger the expansion of pre-existing mutant lung cells via an inflammatory axis and this mechanism may be applicable to a range of cancer risk factors. 

 

The link to the talk will be circulated to those who have booked their place shortly, so keep an eye on your University email.

 

We hope you are excited and are looking forward to this talk just like we are!